BiopestPeptidV1, Main, Exploration, bibRecord, 001715

Control of litchi downy blight by zeamines produced by Dickeya zeae.

Identifieur interne : 001715 ( Main/Exploration ); précédent : 001714; suivant : 001716

Control of litchi downy blight by zeamines produced by Dickeya zeae.

Auteurs : Lisheng Liao [République populaire de Chine] ; Jianuan Zhou [République populaire de Chine] ; Huishan Wang [République populaire de Chine] ; Fei He [République populaire de Chine] ; Shiyin Liu [République populaire de Chine] ; Zide Jiang [République populaire de Chine] ; Shaohua Chen [République populaire de Chine] ; Lian-Hui Zhang [République populaire de Chine, Singapour]

Source :

Scientific reports [ 2045-2322 ] ; 2015.

RBID : pubmed:26499339

Descripteurs français

KwdFr :
- Antibactériens (isolement et purification), Antibactériens (pharmacologie), Antifongiques (isolement et purification), Antifongiques (pharmacologie), Enterobacteriaceae (composition chimique), Germination (effets des médicaments et des substances chimiques), Litchi (microbiologie), Macrolides (isolement et purification), Macrolides (pharmacologie), Phytophthora (effets des médicaments et des substances chimiques), Polyamines (isolement et purification), Polyamines (pharmacologie), Sporanges (effets des médicaments et des substances chimiques), Tests de sensibilité microbienne (MeSH).
MESH :
- composition chimique : Enterobacteriaceae.
- effets des médicaments et des substances chimiques : Germination, Phytophthora, Sporanges.
- isolement et purification : Antibactériens, Antifongiques, Macrolides, Polyamines.
- microbiologie : Litchi.
- pharmacologie : Antibactériens, Antifongiques, Macrolides, Polyamines.
- Tests de sensibilité microbienne.

English descriptors

KwdEn :
- Anti-Bacterial Agents (isolation & purification), Anti-Bacterial Agents (pharmacology), Antifungal Agents (isolation & purification), Antifungal Agents (pharmacology), Enterobacteriaceae (chemistry), Germination (drug effects), Litchi (microbiology), Macrolides (isolation & purification), Macrolides (pharmacology), Microbial Sensitivity Tests (MeSH), Phytophthora (drug effects), Polyamines (isolation & purification), Polyamines (pharmacology), Sporangia (drug effects).
MESH :
- chemical , isolation & purification : Anti-Bacterial Agents, Antifungal Agents, Macrolides, Polyamines.
- chemical , pharmacology : Anti-Bacterial Agents, Antifungal Agents, Macrolides, Polyamines.
- chemistry : Enterobacteriaceae.
- drug effects : Germination, Phytophthora, Sporangia.
- microbiology : Litchi.
- Microbial Sensitivity Tests.

Abstract

Zeamines (ZMS), a class of polyamine-polyketide-nonribosomal peptide produced by bacterial isolate Dickeya zeae, were shown recently to be potent antibiotics against some bacterial pathogens. In this study, the results indicated that ZMS showed antifungal activity against Peronophythora litchii and other fungal pathogens. The activity of ZMS against the oomycete pathogen P. litchi, which causes the devastating litchi downy blight, was further investigated under in vitro and in vivo conditions. ZMS displayed potent inhibitory activity against the mycelial growth and sporangia germination of P. litchii. At a concentration of 2 μg/mL, about 99% of the sporangia germination was inhibited. Scanning electron microscopy and transmission electron microscopy analyses showed that treatment with ZMS could cause substantial damages to the oomycete endomembrane system. Furthermore, treatment of litchi fruits with ZMS solution significantly (P < 0.05) reduced the fruits decay and peel browning caused by P. litchii infection during storage at 28 °C. Taken together, our results provide useful clues on the antifungal mechanisms of ZMS, and highlight the promising potentials of ZMS as a fungicide, which in particular, may be useful for prevention and control of litchi fruits decay and browning caused by P. litchii infection during storage and transportation.

DOI: 10.1038/srep15719
PubMed: 26499339
PubMed Central: PMC4620559

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 001357
to stream Main, to step Curation: 001357

Le document en format XML

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<term>Antifungal Agents (pharmacology)</term>
<term>Enterobacteriaceae (chemistry)</term>
<term>Germination (drug effects)</term>
<term>Litchi (microbiology)</term>
<term>Macrolides (isolation & purification)</term>
<term>Macrolides (pharmacology)</term>
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<term>Antibactériens (pharmacologie)</term>
<term>Antifongiques (isolement et purification)</term>
<term>Antifongiques (pharmacologie)</term>
<term>Enterobacteriaceae (composition chimique)</term>
<term>Germination (effets des médicaments et des substances chimiques)</term>
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<term>Macrolides (pharmacologie)</term>
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<term>Antifungal Agents</term>
<term>Macrolides</term>
<term>Polyamines</term>
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<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-Bacterial Agents</term>
<term>Antifungal Agents</term>
<term>Macrolides</term>
<term>Polyamines</term>
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<term>Phytophthora</term>
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<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Germination</term>
<term>Phytophthora</term>
<term>Sporanges</term>
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<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Antibactériens</term>
<term>Antifongiques</term>
<term>Macrolides</term>
<term>Polyamines</term>
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<keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Litchi</term>
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<front><div type="abstract" xml:lang="en">Zeamines (ZMS), a class of polyamine-polyketide-nonribosomal peptide produced by bacterial isolate Dickeya zeae, were shown recently to be potent antibiotics against some bacterial pathogens. In this study, the results indicated that ZMS showed antifungal activity against Peronophythora litchii and other fungal pathogens. The activity of ZMS against the oomycete pathogen P. litchi, which causes the devastating litchi downy blight, was further investigated under in vitro and in vivo conditions. ZMS displayed potent inhibitory activity against the mycelial growth and sporangia germination of P. litchii. At a concentration of 2 μg/mL, about 99% of the sporangia germination was inhibited. Scanning electron microscopy and transmission electron microscopy analyses showed that treatment with ZMS could cause substantial damages to the oomycete endomembrane system. Furthermore, treatment of litchi fruits with ZMS solution significantly (P < 0.05) reduced the fruits decay and peel browning caused by P. litchii infection during storage at 28 °C. Taken together, our results provide useful clues on the antifungal mechanisms of ZMS, and highlight the promising potentials of ZMS as a fungicide, which in particular, may be useful for prevention and control of litchi fruits decay and browning caused by P. litchii infection during storage and transportation. </div>
</front>
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<ELocationID EIdType="doi" ValidYN="Y">10.1038/srep15719</ELocationID>
<Abstract><AbstractText>Zeamines (ZMS), a class of polyamine-polyketide-nonribosomal peptide produced by bacterial isolate Dickeya zeae, were shown recently to be potent antibiotics against some bacterial pathogens. In this study, the results indicated that ZMS showed antifungal activity against Peronophythora litchii and other fungal pathogens. The activity of ZMS against the oomycete pathogen P. litchi, which causes the devastating litchi downy blight, was further investigated under in vitro and in vivo conditions. ZMS displayed potent inhibitory activity against the mycelial growth and sporangia germination of P. litchii. At a concentration of 2 μg/mL, about 99% of the sporangia germination was inhibited. Scanning electron microscopy and transmission electron microscopy analyses showed that treatment with ZMS could cause substantial damages to the oomycete endomembrane system. Furthermore, treatment of litchi fruits with ZMS solution significantly (P < 0.05) reduced the fruits decay and peel browning caused by P. litchii infection during storage at 28 °C. Taken together, our results provide useful clues on the antifungal mechanisms of ZMS, and highlight the promising potentials of ZMS as a fungicide, which in particular, may be useful for prevention and control of litchi fruits decay and browning caused by P. litchii infection during storage and transportation. </AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Liao</LastName>
<ForeName>Lisheng</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Guangdong Province Key Laboratory of Microbial Signals and Disease Control, South China Agricultural University, Guangzhou 510642, Peoples' Republic of China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Guangdong Innovative and Entepreneurial Research Team of Sociomicrobiology Basic Science and Frontier Technology, South China Agricultural University, Guangzhou 510642, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhou</LastName>
<ForeName>Jianuan</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Guangdong Province Key Laboratory of Microbial Signals and Disease Control, South China Agricultural University, Guangzhou 510642, Peoples' Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Huishan</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Guangdong Province Key Laboratory of Microbial Signals and Disease Control, South China Agricultural University, Guangzhou 510642, Peoples' Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>He</LastName>
<ForeName>Fei</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Guangdong Province Key Laboratory of Microbial Signals and Disease Control, South China Agricultural University, Guangzhou 510642, Peoples' Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Liu</LastName>
<ForeName>Shiyin</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Guangdong Province Key Laboratory of Microbial Signals and Disease Control, South China Agricultural University, Guangzhou 510642, Peoples' Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jiang</LastName>
<ForeName>Zide</ForeName>
<Initials>Z</Initials>
<AffiliationInfo><Affiliation>Guangdong Province Key Laboratory of Microbial Signals and Disease Control, South China Agricultural University, Guangzhou 510642, Peoples' Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Shaohua</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Guangdong Province Key Laboratory of Microbial Signals and Disease Control, South China Agricultural University, Guangzhou 510642, Peoples' Republic of China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), 61 Biopolis Drive, Proteos, Singapore 138673, Republic of Singapore.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Lian-Hui</ForeName>
<Initials>LH</Initials>
<AffiliationInfo><Affiliation>Guangdong Province Key Laboratory of Microbial Signals and Disease Control, South China Agricultural University, Guangzhou 510642, Peoples' Republic of China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), 61 Biopolis Drive, Proteos, Singapore 138673, Republic of Singapore.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Biological Sciences, National University of Singapore, Republic of Singapore.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2015</Year>
<Month>10</Month>
<Day>26</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Sci Rep</MedlineTA>
<NlmUniqueID>101563288</NlmUniqueID>
<ISSNLinking>2045-2322</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000900">Anti-Bacterial Agents</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000935">Antifungal Agents</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D018942">Macrolides</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D011073">Polyamines</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C547236">zeamine</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000900" MajorTopicYN="N">Anti-Bacterial Agents</DescriptorName>
<QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000935" MajorTopicYN="N">Antifungal Agents</DescriptorName>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D004755" MajorTopicYN="N">Enterobacteriaceae</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018525" MajorTopicYN="N">Germination</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D032125" MajorTopicYN="N">Litchi</DescriptorName>
<QualifierName UI="Q000382" MajorTopicYN="Y">microbiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018942" MajorTopicYN="N">Macrolides</DescriptorName>
<QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008826" MajorTopicYN="N">Microbial Sensitivity Tests</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010838" MajorTopicYN="N">Phytophthora</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011073" MajorTopicYN="N">Polyamines</DescriptorName>
<QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058432" MajorTopicYN="N">Sporangia</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year>
<Month>06</Month>
<Day>12</Day>
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<PubMedPubDate PubStatus="accepted"><Year>2015</Year>
<Month>10</Month>
<Day>02</Day>
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<PubMedPubDate PubStatus="entrez"><Year>2015</Year>
<Month>10</Month>
<Day>27</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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<PubMedPubDate PubStatus="pubmed"><Year>2015</Year>
<Month>10</Month>
<Day>27</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2016</Year>
<Month>8</Month>
<Day>31</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
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<PublicationStatus>epublish</PublicationStatus>
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<affiliations><list><country><li>République populaire de Chine</li>
<li>Singapour</li>
</country>
<region><li>Guangdong</li>
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<tree><country name="République populaire de Chine"><region name="Guangdong"><name sortKey="Liao, Lisheng" sort="Liao, Lisheng" uniqKey="Liao L" first="Lisheng" last="Liao">Lisheng Liao</name>
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<name sortKey="Chen, Shaohua" sort="Chen, Shaohua" uniqKey="Chen S" first="Shaohua" last="Chen">Shaohua Chen</name>
<name sortKey="He, Fei" sort="He, Fei" uniqKey="He F" first="Fei" last="He">Fei He</name>
<name sortKey="Jiang, Zide" sort="Jiang, Zide" uniqKey="Jiang Z" first="Zide" last="Jiang">Zide Jiang</name>
<name sortKey="Liao, Lisheng" sort="Liao, Lisheng" uniqKey="Liao L" first="Lisheng" last="Liao">Lisheng Liao</name>
<name sortKey="Liu, Shiyin" sort="Liu, Shiyin" uniqKey="Liu S" first="Shiyin" last="Liu">Shiyin Liu</name>
<name sortKey="Wang, Huishan" sort="Wang, Huishan" uniqKey="Wang H" first="Huishan" last="Wang">Huishan Wang</name>
<name sortKey="Zhang, Lian Hui" sort="Zhang, Lian Hui" uniqKey="Zhang L" first="Lian-Hui" last="Zhang">Lian-Hui Zhang</name>
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	Serveur d'exploration sur les peptides biopesticides
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Control of litchi downy blight by zeamines produced by Dickeya zeae.

Control of litchi downy blight by zeamines produced by Dickeya zeae.

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